Drug Screening

BACE Inhibitors A ϐ-amyloid cleaving enzyme (BACE) inhibitor acutely reduces CSF and plasma levels of Aϐ in a dose dependent manner
Aϐ Antibody Strategies The administration of a vaccine targeting fibrillar Aϐ reduced Aϐ deposition, but did not significantly modify longitudinal cognitive measures.
Comparative Drug Screening The effects of putative AD therapeutics on CSF biomarkers in aged dogs provides a rapid screen in a higher mammalian model that naturally develops AD-like pathology. We have experience in conducting relatively rapid screens for studying the effect of multiple NCEs on CSF biomarkers to support the lead optimization process which can be followed up with more extensive studies on selected compounds.