Publications

---

Publications

• Guy A. Higgins, Nicole K. Carroll, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel, Julia Izhakova, Lilia Magomedova, Ines DeLannoy, Edward M. Sellers, Low Doses of Psilocybin and Ketamine Enhance Motivation and Attention in Poor Performing Rats: Evidence for an Antidepressant Property Frontiers in Pharmacology, February 2021

  [View]

• H. Benson Peng, Keumhan Noh, Sophie R. Pan, Victor Saldivia, Sylvia Serson, Anja Toscan, Inés A.M. de Lannoy, K. Sandy Pang Human Amyloid-β 40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo Drug Metabolism & Disposition 48:944–955, October 2020

  [Pubmed]

• Evaluation of Selective 5-HT2C Agonists in Acute Seizure Models. Silenieks LB, Carroll NK, Van Niekerk A, Van Niekerk E, Taylor C, Upton N, & Higgins GA. ACS chemical neuroscience (2019).

  [Pubmed]

• Higgins GA, Silenieks LB, MacMillan C, Zeeb FD, & Thevarkunnel S. Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task. Behavioural brain research 348 (2018): 201-210.

  [Pubmed]

• Higgins GA, Silenieks LB, Patrick A, De Lannoy IA, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA & Berg KA. Studies to examine potential tolerability differences between the 5-HT2C receptor selective agonists lorcaserin and CP-809101. ACS chemical neuroscience 8.5 (2017): 1074-1084.

  [Pubmed]

• Higgins GA, Silenieks LB. The 5‐Choice Serial Reaction Time Task. Current protocols in pharmacology (2017): 5-49.

  [Pubmed]

• Higgins GA, Silenieks LB, Altherr EB, MacMillan C, Fletcher PK, & Pratt WE. Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists. Psychopharmacology 233.14 (2016): 2841-2856.

  [Pubmed]

• Higgins GA, Silenieks LB, MacMillan C, Sevo J, Zeeb FD, & Thevarkunnel S. Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment. Behavioural brain research 311 (2016): 1-14.

  [Pubmed]

• Higgins GA, Silenieks LB, Van Niekerk A, Desnoyer J, Patrick A, Lau W, & Thevarkunnel S. Enduring attentional deficits in rats treated with a peripheral nerve injury. Behavioural brain research 286 (2015): 347-355

  [Pubmed]

• Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA. Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine: An Intracerebral Microdialysis Study in Conscious Rats. Pharm Res. 2014 Oct 16. [Epub ahead of print]

  [Pubmed]

• Aimone LD1, de Lannoy IA. Overview of pharmacokinetics. Curr Protoc Pharmacol. 2014 Sep 2;66:7.1.1-7.1.31.

  [Pubmed]

• Fan J, de Lannoy IA. Pharmacokinetics. Biochem Pharmacol. 2014 Jan 1;87(1):93-120. Review.

  [Pubmed]

• Gary N.Y. Chan, Victor Saldivia, Yingo Yang, Henrianna Pang, Inés de Lannoy, and Reina Bendayan. In vivo Induction of P-Glycoprotein expression at the mouse blood-brain barrier: an Intracerebral microdialysis study. Journal of Neurochemistry. 2013;127:342-352

  [Pubmed]

• Lau W, Dykstra C, Thevarkunnel S, Silenieks LB, de Lannoy IA, Lee DK, Higgins GA. A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain Neuropharmacology. 2013; 73: 204-215

  [Pubmed]

• Silenieks LB, Koch E, Higgins GA Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue Phytomedicine. 2013; 20:172-177

  [Pubmed]

• Higgins GA, Silenieks LB, Lau W, de Lannoy IA, Lee DK, Izhakova J, Coen K, Le AD, Fletcher PJ. Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food and nicotine and on side effect profiles Psychopharmacology. 2013; 226: 475-490.

  [Pubmed]

• Higgins G.A., Silenieks L.B., Roβmann A., Rizos Z., Noble K., Soko A.D., Fletcher P.J. The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to effect on feeding behavior and impulse control Neuropsychopharmacology. 2012; 37: 1177-1191

  [Pubmed]

• Fletcher PJ, Rizos Z, Noble K, Soko AD, Silenieks LB, Lê AD, Higgins GA. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5HT(2A) receptor antagonist M100907 on nicotine self-administration and reinstatement. Neuropharmacology (2012); 62(7)2288-98.

  [Pubmed]

• Araujo, J.A., Nobrega, J.N., Raymond, R., Milgram, N.W. Aged dogs demonstrate both increased sensitivity to scopolamine and decreased muscarinic receptor density Pharmacology, Biochemistry and Behavior, 2011; 98(2): 203-209.

  [Pubmed]

• Araujo, J.A., Greig, N.H., Ingram, D.K., Sandin, J., de Rivera, C., Milgram, N.W. Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs Journal of Alzheimer's Disease, 2011; 26(1):143-155.

  [Pubmed]

Posters and Abstracts

• Rosahl TW, Varty GB, Smith SM, Gentzel R, Carroll N, Silenieks L, Higgins GA, Schachter J. A novel tau transgenic mouse model overexpressing human tau and an aggregation-prone tau sequence shows tau hyperphosphorylation and behavioral deficits in the Morris Water Maze. Society for Neuroscience meeting, Chicago, October 19-23 2019
• Higgins GA, Brown M, MacMillan C, Silenieks LB. Effect of lorcaserin and atomoxetine in two tests of compulsive action. Society for Neuroscience meeting, Chicago, October 19-23 2019
• J.A. Araujo and M.J. Winhall Pharmacological and Cross Validation of a Translational Pain Questionnaire Assessing Behavioral Quality of Life Measures Across Acute Urate-Induced Pain in dogs and a Naturalistic Canine Model of Osteoarthritic Pain Intervivo Solutions

  [Download]

• Joseph A Araujo BSc¹, Sergi Segarra DVM MSc PhD², Andrea Paradis BS³, Sandy Thevarkunnel PhD³ and Norton W Milgram PhD⁴ Supplementation with a novel lipid extract improves frontal lobe linked cognitive deficits in an aged beagle model of Alzheimer’s disease Alzheimer’s Association International Conference, July 22-26, 2018, Chicago, USA

  [Download]

• Inés de Lannoy¹, Masakazu Kakuni², Sophie Pan¹, Julia Izhakova¹, Alexander Kitayev² and Yoshio Morikawa² Ketoconazole inhibition of midazolam metabolism to 1’OH-midazolam in the chimeric mouse with humanized liver and the SCID mouse Intervivo Solutions, Canada and PhoenixBio, Japan

  [Download]

• J.A .Araujo BSc¹, S. Kelly², J. Baulk², D Baronowski³, and J. Gabriele³ Validation of a Translational Pain Questionnaire Assessing Behavioral Quality of Life Measures in a Naturalistic Canine Model of Osteoarthritic Pain and Urate-Induced Pain SFN2016 meeting

  [Download]

• N.W. Milgram,. J.A. Caskanette, A. Van Niekerk, A. Patrick, L.B. Silenieks, W. Lau, S. Thevarkunnel, J.A. Araujo, G.A. Higgins A longitudinal study of PINK1 and PARK7 KO rats Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

  [Download]

• G. A. Higgins , L. B. Silenieks , C. MacMillan , J. Sevo , F. D. Zeeb , S. Thevarkunnel Characterisation of two NMDA NR2B subunit (grin2b) antagonists across tests of impulsivity and attention Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

  [Download]

• J. A. Araujo , S. Kelly , J. Baulk , D. Araujo , C. De Rivera , D. Baronowski , J. Gabriele Validation of a translational pain questionnaire assessing behavioral quality of life measures in a naturalistic canine model of osteoarthritic pain and urate-induced pain Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

  [Download]

• Higgins GA, Silenieks LB, Patrick A, DeLannoy IAM, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA, Berg KA. A study of the selective 5-HT2C agonists Lorcaserin and CP-809101 on side-effect profile, CNS penetration and functional selectivity. Poster presented at SFN 2015 meeting in Chicago
• Higgins GA, Silenieks LB, Altherr EB, Patrick A, MacMillan C, DeLannoy IAM, Fletcher PJ, Pratt WE. A study of selective 5-HT2C agonists Lorcaserin and CP-809101 on measures of impulsivity and food reinstatement in the rat. Poster presented at EBPS meeting 2015 in Verona, Italy
• ¹J.A. Araujo, ²J. Caskanette, ²A. Patrick, ¹W. Lau, ³B. Milgram, J. Bautista, ⁴L. Balenci, ⁴J.S. Andrews, ⁴^,⁵S. Annedi, 1, ²G.A. Higgins Evaluation of synthetic derivatives of medium chain triglyceride (mct) fatty acids in mice SFN2015 meeting, October 17-21. Chicago

  [Download]

• Higgins GA, Desnoyer J, Van Niekerk A, Silenieks LB, Lau W, Thevarkunnel S, Delay J, Dobson H. A backtranslational study of the selective 5-HT2C agonist lorcaserin in two rat obesity models Society for Neuroscience meeting, San Diego, Nov 9-13th 2013.

  [Download]

• Higgins GA, Lau W, Desnoyer J, DeLannoy IAM, Milgram NW Evaluation of the Zucker fatty rat as a model of diabetic neuropathy Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

  [Download]

• Joseph A Araujo, Kate Sokolnicki, Jacob Hesterman, Jack Hoppin, Dale E. Araujo, Howard Dobson Aged Beagle Dogs Demonstrate Reduced Brain Metabolism Measured By FDG-PET-MR Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

  [Download]

• C. de Rivera, B. Chakravarthy, S. Kelly, J. Baulk, M.L. Brooks, B. Milgram, J.A. Araujo The reliability and effects of age on CSF measures of b-Amyloid and tau in beagle dogs: implications for a natural animal model of Alzheimer's disease progression Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

  [Download]

• Higgins GA, Silenieks LB, Lau W, De Lannoy IAM, Lee DKH, Le AD, Fletcher PJ Characterization of the highly selective 5-HT2C receptor agonists lorcaserin and CP-809101 on food and nicotine motivated behaviors in the rat Society for Neuroscience meeting, New Orleans, Oct 13-17th 2012, Poster

  [Download]

• Higgins GA, Lau W, Dykstra C, Silenieks LB, De Lannoy IAM, Lee DKH, Pang HY, Araujo JA Characterisation of acute and chronic administration of pregabalin (Lyrica®) on multiple endpoints in the rat spared nerve injury model. Society for Neuroscience meeting, New Orleans, Oct 13-17th 2012, Poster

  [Download]

• Winnie Lau, Crystal Dykstra, Leo B. Silenieks, Mogjan Mohagheghi, Sandy Thevarkunnel, Ines A.M. de Lannoy, David K.H. Lee, Joseph Araujo, Guy A. Higgins Characterisation of Pregabalin (Lyrica ®) on multiple behavioural endpoints in the rat spared nerve injury model IASP meeting, Milan, Italy, August 27-30th 2012; poster PT222

  [Download]

• Joseph A. Araujo, Guy A. Higgins, Christina de Rivera, Norton W. Milgram Evaluation of translational disease biomarkers in the aged dog: The effects of age and BACE inhibition on CSF amyloid Alzheimer's Association International Conference, 2011

  [Download]

• Guy Higgins, Leo B. Silenieks, Winnie Lau, Paul J. Fletcher Examination of the 5-HT2C receptor agonists lorcaserin and Ro 60-0175 against nicotine discrimination and dependence in the rat Society for Neuroscience meeting, Washington, D.C., November 12-16th 2011, poster

  [Download]

• Guy A. Higgins, Leo Silenieks, Winnie Lau, Sandy Thevarkunnel, Alan Henderson, Nicholas Moore Characterisation of the 5-HT6 receptor antagonist, SB-742457, on cognitive test performance in the rat Society for Neuroscience meeting, San Diego, November 13-17th 2010

  [Download]

• Guy A. Higgins, Leo Silenieks, Zoe Rizos, Kevin Noble, Paul J. Fletcher The selective 5-HT2C receptor agonist, lorcaserin, reduces indices of nicotine reward as well as food intake in the rat Society for Neuroscience meeting, San Diego, November 13-17th 2010

  [Download]