Publications

---

Publications

• H. Benson Peng, Keumhan Noh, Sophie R. Pan, Victor Saldivia, Sylvia Serson, Anja Toscan, Inés A.M. de Lannoy, K. Sandy Pang Human Amyloid-β 40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo Drug Metabolism & Disposition 48:944–955, October 2020

  [Pubmed]

• Evaluation of Selective 5-HT2C Agonists in Acute Seizure Models. Silenieks LB, Carroll NK, Van Niekerk A, Van Niekerk E, Taylor C, Upton N, & Higgins GA. ACS chemical neuroscience (2019).

  [Pubmed]

• Higgins GA, Silenieks LB, MacMillan C, Zeeb FD, & Thevarkunnel S. Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task. Behavioural brain research 348 (2018): 201-210.

  [Pubmed]

• Higgins GA, Silenieks LB, Patrick A, De Lannoy IA, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA & Berg KA. Studies to examine potential tolerability differences between the 5-HT2C receptor selective agonists lorcaserin and CP-809101. ACS chemical neuroscience 8.5 (2017): 1074-1084.

  [Pubmed]

• Higgins GA, Silenieks LB. The 5‐Choice Serial Reaction Time Task. Current protocols in pharmacology (2017): 5-49.

  [Pubmed]

• Higgins GA, Silenieks LB, Altherr EB, MacMillan C, Fletcher PK, & Pratt WE. Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists. Psychopharmacology 233.14 (2016): 2841-2856.

  [Pubmed]

• Higgins GA, Silenieks LB, MacMillan C, Sevo J, Zeeb FD, & Thevarkunnel S. Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment. Behavioural brain research 311 (2016): 1-14.

  [Pubmed]

• Higgins GA, Silenieks LB, Van Niekerk A, Desnoyer J, Patrick A, Lau W, & Thevarkunnel S. Enduring attentional deficits in rats treated with a peripheral nerve injury. Behavioural brain research 286 (2015): 347-355

  [Pubmed]

• Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA. Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine: An Intracerebral Microdialysis Study in Conscious Rats. Pharm Res. 2014 Oct 16. [Epub ahead of print]

  [Pubmed]

• Aimone LD1, de Lannoy IA. Overview of pharmacokinetics. Curr Protoc Pharmacol. 2014 Sep 2;66:7.1.1-7.1.31.

  [Pubmed]

• Fan J, de Lannoy IA. Pharmacokinetics. Biochem Pharmacol. 2014 Jan 1;87(1):93-120. Review.

  [Pubmed]

• Gary N.Y. Chan, Victor Saldivia, Yingo Yang, Henrianna Pang, Inés de Lannoy, and Reina Bendayan. In vivo Induction of P-Glycoprotein expression at the mouse blood-brain barrier: an Intracerebral microdialysis study. Journal of Neurochemistry. 2013;127:342-352

  [Pubmed]

• Lau W, Dykstra C, Thevarkunnel S, Silenieks LB, de Lannoy IA, Lee DK, Higgins GA. A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain Neuropharmacology. 2013; 73: 204-215

  [Pubmed]

• Silenieks LB, Koch E, Higgins GA Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue Phytomedicine. 2013; 20:172-177

  [Pubmed]

• Higgins GA, Silenieks LB, Lau W, de Lannoy IA, Lee DK, Izhakova J, Coen K, Le AD, Fletcher PJ. Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food and nicotine and on side effect profiles Psychopharmacology. 2013; 226: 475-490.

  [Pubmed]

• Higgins G.A., Silenieks L.B., Roβmann A., Rizos Z., Noble K., Soko A.D., Fletcher P.J. The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to effect on feeding behavior and impulse control Neuropsychopharmacology. 2012; 37: 1177-1191

  [Pubmed]

• Fletcher PJ, Rizos Z, Noble K, Soko AD, Silenieks LB, Lê AD, Higgins GA. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5HT(2A) receptor antagonist M100907 on nicotine self-administration and reinstatement. Neuropharmacology (2012); 62(7)2288-98.

  [Pubmed]

• Araujo, J.A., Nobrega, J.N., Raymond, R., Milgram, N.W. Aged dogs demonstrate both increased sensitivity to scopolamine and decreased muscarinic receptor density Pharmacology, Biochemistry and Behavior, 2011; 98(2): 203-209.

  [Pubmed]

• Araujo, J.A., Greig, N.H., Ingram, D.K., Sandin, J., de Rivera, C., Milgram, N.W. Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs Journal of Alzheimer's Disease, 2011; 26(1):143-155.

  [Pubmed]

Posters and Abstracts

• Rosahl TW, Varty GB, Smith SM, Gentzel R, Carroll N, Silenieks L, Higgins GA, Schachter J. A novel tau transgenic mouse model overexpressing human tau and an aggregation-prone tau sequence shows tau hyperphosphorylation and behavioral deficits in the Morris Water Maze. Society for Neuroscience meeting, Chicago, October 19-23 2019
• Higgins GA, Brown M, MacMillan C, Silenieks LB. Effect of lorcaserin and atomoxetine in two tests of compulsive action. Society for Neuroscience meeting, Chicago, October 19-23 2019
• J.A. Araujo and M.J. Winhall Pharmacological and Cross Validation of a Translational Pain Questionnaire Assessing Behavioral Quality of Life Measures Across Acute Urate-Induced Pain in dogs and a Naturalistic Canine Model of Osteoarthritic Pain Intervivo Solutions

  [Download]

• Joseph A Araujo BSc¹, Sergi Segarra DVM MSc PhD², Andrea Paradis BS³, Sandy Thevarkunnel PhD³ and Norton W Milgram PhD⁴ Supplementation with a novel lipid extract improves frontal lobe linked cognitive deficits in an aged beagle model of Alzheimer’s disease Alzheimer’s Association International Conference, July 22-26, 2018, Chicago, USA

  [Download]

• Inés de Lannoy¹, Masakazu Kakuni², Sophie Pan¹, Julia Izhakova¹, Alexander Kitayev² and Yoshio Morikawa² Ketoconazole inhibition of midazolam metabolism to 1’OH-midazolam in the chimeric mouse with humanized liver and the SCID mouse Intervivo Solutions, Canada and PhoenixBio, Japan

  [Download]

• J.A .Araujo BSc¹, S. Kelly², J. Baulk², D Baronowski³, and J. Gabriele³ Validation of a Translational Pain Questionnaire Assessing Behavioral Quality of Life Measures in a Naturalistic Canine Model of Osteoarthritic Pain and Urate-Induced Pain SFN2016 meeting

  [Download]

• N.W. Milgram,. J.A. Caskanette, A. Van Niekerk, A. Patrick, L.B. Silenieks, W. Lau, S. Thevarkunnel, J.A. Araujo, G.A. Higgins A longitudinal study of PINK1 and PARK7 KO rats Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

  [Download]

• G. A. Higgins , L. B. Silenieks , C. MacMillan , J. Sevo , F. D. Zeeb , S. Thevarkunnel Characterisation of two NMDA NR2B subunit (grin2b) antagonists across tests of impulsivity and attention Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

  [Download]

• J. A. Araujo , S. Kelly , J. Baulk , D. Araujo , C. De Rivera , D. Baronowski , J. Gabriele Validation of a translational pain questionnaire assessing behavioral quality of life measures in a naturalistic canine model of osteoarthritic pain and urate-induced pain Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

  [Download]

• Higgins GA, Silenieks LB, Patrick A, DeLannoy IAM, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA, Berg KA. A study of the selective 5-HT2C agonists Lorcaserin and CP-809101 on side-effect profile, CNS penetration and functional selectivity. Poster presented at SFN 2015 meeting in Chicago
• Higgins GA, Silenieks LB, Altherr EB, Patrick A, MacMillan C, DeLannoy IAM, Fletcher PJ, Pratt WE. A study of selective 5-HT2C agonists Lorcaserin and CP-809101 on measures of impulsivity and food reinstatement in the rat. Poster presented at EBPS meeting 2015 in Verona, Italy
• ¹J.A. Araujo, ²J. Caskanette, ²A. Patrick, ¹W. Lau, ³B. Milgram, J. Bautista, ⁴L. Balenci, ⁴J.S. Andrews, ⁴^,⁵S. Annedi, 1, ²G.A. Higgins Evaluation of synthetic derivatives of medium chain triglyceride (mct) fatty acids in mice SFN2015 meeting, October 17-21. Chicago

  [Download]

• Higgins GA, Desnoyer J, Van Niekerk A, Silenieks LB, Lau W, Thevarkunnel S, Delay J, Dobson H. A backtranslational study of the selective 5-HT2C agonist lorcaserin in two rat obesity models Society for Neuroscience meeting, San Diego, Nov 9-13th 2013.

  [Download]

• Higgins GA, Lau W, Desnoyer J, DeLannoy IAM, Milgram NW Evaluation of the Zucker fatty rat as a model of diabetic neuropathy Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

  [Download]

• Joseph A Araujo, Kate Sokolnicki, Jacob Hesterman, Jack Hoppin, Dale E. Araujo, Howard Dobson Aged Beagle Dogs Demonstrate Reduced Brain Metabolism Measured By FDG-PET-MR Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

  [Download]

• C. de Rivera, B. Chakravarthy, S. Kelly, J. Baulk, M.L. Brooks, B. Milgram, J.A. Araujo The reliability and effects of age on CSF measures of b-Amyloid and tau in beagle dogs: implications for a natural animal model of Alzheimer's disease progression Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

  [Download]

• Higgins GA, Silenieks LB, Lau W, De Lannoy IAM, Lee DKH, Le AD, Fletcher PJ Characterization of the highly selective 5-HT2C receptor agonists lorcaserin and CP-809101 on food and nicotine motivated behaviors in the rat Society for Neuroscience meeting, New Orleans, Oct 13-17th 2012, Poster

  [Download]

• Higgins GA, Lau W, Dykstra C, Silenieks LB, De Lannoy IAM, Lee DKH, Pang HY, Araujo JA Characterisation of acute and chronic administration of pregabalin (Lyrica®) on multiple endpoints in the rat spared nerve injury model. Society for Neuroscience meeting, New Orleans, Oct 13-17th 2012, Poster

  [Download]

• Winnie Lau, Crystal Dykstra, Leo B. Silenieks, Mogjan Mohagheghi, Sandy Thevarkunnel, Ines A.M. de Lannoy, David K.H. Lee, Joseph Araujo, Guy A. Higgins Characterisation of Pregabalin (Lyrica ®) on multiple behavioural endpoints in the rat spared nerve injury model IASP meeting, Milan, Italy, August 27-30th 2012; poster PT222

  [Download]

• Joseph A. Araujo, Guy A. Higgins, Christina de Rivera, Norton W. Milgram Evaluation of translational disease biomarkers in the aged dog: The effects of age and BACE inhibition on CSF amyloid Alzheimer's Association International Conference, 2011

  [Download]

• Guy Higgins, Leo B. Silenieks, Winnie Lau, Paul J. Fletcher Examination of the 5-HT2C receptor agonists lorcaserin and Ro 60-0175 against nicotine discrimination and dependence in the rat Society for Neuroscience meeting, Washington, D.C., November 12-16th 2011, poster

  [Download]

• Guy A. Higgins, Leo Silenieks, Winnie Lau, Sandy Thevarkunnel, Alan Henderson, Nicholas Moore Characterisation of the 5-HT6 receptor antagonist, SB-742457, on cognitive test performance in the rat Society for Neuroscience meeting, San Diego, November 13-17th 2010

  [Download]

• Guy A. Higgins, Leo Silenieks, Zoe Rizos, Kevin Noble, Paul J. Fletcher The selective 5-HT2C receptor agonist, lorcaserin, reduces indices of nicotine reward as well as food intake in the rat Society for Neuroscience meeting, San Diego, November 13-17th 2010

  [Download]