Publications

Papers

Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA. Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine: An Intracerebral Microdialysis Study in Conscious Rats. Pharm Res. 2014 Oct 16. [Epub ahead of print] [Pubmed]
Fan J, de Lannoy IA. Pharmacokinetics. Biochem Pharmacol. 2014 Jan 1;87(1):93-120. Review. [Pubmed]
Aimone LD1, de Lannoy IA. Overview of pharmacokinetics. Curr Protoc Pharmacol. 2014 Sep 2;66:7.1.1-7.1.31. [Pubmed]
Gary N.Y. Chan, Victor Saldivia, Yingo Yang, Henrianna Pang, Inés de Lannoy, and Reina Bendayan. In vivo Induction of P-Glycoprotein expression at the mouse blood-brain barrier: an Intracerebral microdialysis study. Journal of Neurochemistry. 2013;127:342-352 [Pubmed]
Lau W, Dykstra C, Thevarkunnel S, Silenieks LB, de Lannoy IA, Lee DK, Higgins GA. A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain Neuropharmacology. 2013; 73: 204-215 [Pubmed]
Silenieks LB, Koch E, Higgins GA Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue Phytomedicine. 2013; 20:172-177 [Pubmed]
Higgins GA, Silenieks LB, Lau W, de Lannoy IA, Lee DK, Izhakova J, Coen K, Le AD, Fletcher PJ. Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food and nicotine and on side effect profiles Psychopharmacology. 2013; 226: 475-490. [Pubmed]
Higgins G.A., Silenieks L.B., Roβmann A., Rizos Z., Noble K., Soko A.D., Fletcher P.J. The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to effect on feeding behavior and impulse control Neuropsychopharmacology. 2012; 37: 1177-1191 [Pubmed]
Araujo, J.A., Nobrega, J.N., Raymond, R., Milgram, N.W. Aged dogs demonstrate both increased sensitivity to scopolamine and decreased muscarinic receptor density Pharmacology, Biochemistry and Behavior, 2011; 98(2): 203-209. [Pubmed]
Araujo, J.A., Greig, N.H., Ingram, D.K., Sandin, J., de Rivera, C., Milgram, N.W. Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs Journal of Alzheimer's Disease, 2011; 26(1):143-155. [Pubmed]

Abstracts

J. A. Araujo , S. Kelly , J. Baulk , D. Araujo , C. De Rivera , D. Baronowski , J. Gabriele Validation of a translational pain questionnaire assessing behavioral quality of life measures in a naturalistic canine model of osteoarthritic pain and urate-induced pain Society for Neuroscience meeting, San Diego, November 12–16 2016, poster #524.26 [Download]
G. A. Higgins , L. B. Silenieks , C. MacMillan , J. Sevo , F. D. Zeeb , S. Thevarkunnel Characterisation of two NMDA NR2B subunit (grin2b) antagonists across tests of impulsivity and attention Society for Neuroscience meeting, San Diego, November 12–16 2016, poster #396.11 [Download]
N.W. Milgram,. J.A. Caskanette, A. Van Niekerk, A. Patrick, L.B. Silenieks, W. Lau, S. Thevarkunnel, J.A. Araujo, G.A. Higgins A longitudinal study of PINK1 and PARK7 KO rats Society for Neuroscience meeting, San Diego, November 12–16 2016, poster #414.04 [Download]
C. de Rivera, B. Chakravarthy, S. Kelly, J. Baulk, M.L. Brooks, B. Milgram, J.A. Araujo The reliability and effects of age on CSF measures of b-Amyloid and tau in beagle dogs: implications for a natural animal model of Alzheimer's disease progression Society for Neuroscience meeting, San Diego Nov 9-13th 2013. [Download]
Joseph A Araujo, Kate Sokolnicki, Jacob Hesterman, Jack Hoppin, Dale E. Araujo, Howard Dobson Aged Beagle Dogs Demonstrate Reduced Brain Metabolism Measured By FDG-PET-MR Society for Neuroscience meeting, San Diego Nov 9-13th 2013. [Download]
Higgins GA, Lau W, Desnoyer J, DeLannoy IAM, Milgram NW Evaluation of the Zucker fatty rat as a model of diabetic neuropathy Society for Neuroscience meeting, San Diego Nov 9-13th 2013. [Download]
Higgins GA, Desnoyer J, Van Niekerk A, Silenieks LB, Lau W, Thevarkunnel S, Delay J, Dobson H. A backtranslational study of the selective 5-HT2C agonist lorcaserin in two rat obesity models Society for Neuroscience meeting, San Diego, Nov 9-13th 2013. [Download]
Higgins GA, Lau W, Dykstra C, Silenieks LB, De Lannoy IAM, Lee DKH, Pang HY, Araujo JA Characterisation of acute and chronic administration of pregabalin (Lyrica®) on multiple endpoints in the rat spared nerve injury model. Society for Neuroscience meeting, New Orleans, Oct 13-17th 2012, Poster #575.13 [Download]
Higgins GA, Silenieks LB, Lau W, De Lannoy IAM, Lee DKH, Le AD, Fletcher PJ Characterization of the highly selective 5-HT2C receptor agonists lorcaserin and CP-809101 on food and nicotine motivated behaviors in the rat Society for Neuroscience meeting, New Orleans, Oct 13-17th 2012, Poster #875.06 [Download]
Guy Higgins, Leo B. Silenieks, Winnie Lau, Paul J. Fletcher Examination of the 5-HT2C receptor agonists lorcaserin and Ro 60-0175 against nicotine discrimination and dependence in the rat Society for Neuroscience meeting, Washington, D.C., November 12-16th 2011, poster #263.01 [Download]
Joseph A. Araujo, Guy A. Higgins, Christina de Rivera, Norton W. Milgram Evaluation of translational disease biomarkers in the aged dog: The effects of age and BACE inhibition on CSF amyloid Alzheimer's Association International Conference, 2011 [Download]
Winnie Lau, Crystal Dykstra, Leo B. Silenieks, Mogjan Mohagheghi, Sandy Thevarkunnel, Ines A.M. de Lannoy, David K.H. Lee, Joseph Araujo, Guy A. Higgins Characterisation of Pregabalin (Lyrica ®) on multiple behavioural endpoints in the rat spared nerve injury model IASP meeting, Milan, Italy, August 27-30th 2012; poster PT222 [Download]
Guy A. Higgins, Leo Silenieks, Zoe Rizos, Kevin Noble, Paul J. Fletcher The selective 5-HT2C receptor agonist, lorcaserin, reduces indices of nicotine reward as well as food intake in the rat Society for Neuroscience meeting, San Diego, November 13-17th 2010 [Download]
Guy A. Higgins, Leo Silenieks, Winnie Lau, Sandy Thevarkunnel, Alan Henderson, Nicholas Moore Characterisation of the 5-HT6 receptor antagonist, SB-742457, on cognitive test performance in the rat Society for Neuroscience meeting, San Diego, November 13-17th 2010 [Download]